Search on: PROTOPORPHYRINOGEN OXIDASE 
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Descriptor English:   Protoporphyrinogen Oxidase 
Descriptor Spanish:   Protoporfirinógeno-Oxidasa 
Descriptor Portuguese:   Protoporfirinogênio Oxidase 
Synonyms English:   Protoporphyrinogen Dehydrogenase
Protoporphyrinogen IX Oxidase
Protoporphyrinogenase
Protox
Dehydrogenase, Protoporphyrinogen
Oxidase, Protoporphyrinogen
Oxidase, Protoporphyrinogen IX  
Tree Number:   D08.811.682.660.600
D12.776.543.697
Definition English:   A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase. 
Entry Combination - descr/qualif English:   Protoporphyrinogen Oxidase/deficiency use Porphyria, Variegate
 
History Note English:   2006(1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50629 
Unique Identifier:   D050768 

Occurrence in VHL:
 

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